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According to the World Health Organization , epilepsy is a chronic noncommunicable illness of the brain that affects about 50 million people of all ages worldwide. Nearly 80% of the people with epilepsy live in low- and middle-income countries, and about three fourths of those people do not get the treatment they need. In the context of our project, we will focus on refractory (pharmacoresistant) epilepsy, which affect about 30% of epileptic patients, who may suffer from irreversible disabilities and pre-mature deaths. The mechanisms of refractory epilepsy are still unclear; however, many efforts are ongoing into discovery and development of novel antiepileptic agents with better therapeutic profiles. Better understanding of the heterogeneous nature of epilepsy and the multiple complex factors, which contribute to the abnormal neural discharges, will create the basis for progress in development of etiological rather than symptomatic therapies.

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